Regression or shrinking was observed in 31% of patients (seven of 22). Notably, patient 05 (Figure 7) initially received a baseline R score of 6 and a pre-treated tumor volume at 24 cc. After treatment, the patient received an R score of 4 and a post-treated tumor volume of 2.4 cc. Due to the significant regression of the cancer, the patient was eligible to receive surgery. This case is unique because both the tumor volume and the vessel involvement score indicated surgery as a potential option. However, the surgery was not done as it was believed the patient might continue responding to the chemotherapy. Figure 7 frontiersin Figure 7. Patient 05 CT scans for volumetric and perfusion analysis.
Scans of the arterial (a, d) and venous phases (b, e) were used to develop the 3D images (c, f) for 3D analysis. The patient's pre-treated tumor volume was Spain phone number list estimated at 24 cc and the post-treated tumor volume size was 2.4 cc. Initially, patient 05 had a baseline R score of 6 and, through the clinical trials, received a final R score of 4. Due to the significant reduction in both tumor size and receiving an R score of 4, the patient was an eligible candidate for surgery. The Rahmanuddin scoring method (Figure 3) proved to be a good indicator of whether a patient might proceed to surgery.
Post-therapy, the patient had improved to an R score of 7 with a tumor volume of 31 cc. While this was a dramatic drop in volume, the R score did not drop to the necessary score of 5, indicating that surgery was not a viable option. Other treatment possibilities were considered for the patient. Discussion was to define a novel CT imaging perfusion analytical method by observing the treatment response of pancreatic cancer patients in a neoadjuvant-treated population to determine whether patients can become appropriate candidates for surgery. Observing reduction in vascular involvement between pre-treatment and post-treatment imaging was associated with a higher likelihood of proceeding with surgery.